The Association of Ponderal Benznidazole with its Ultra-high Diluted Formula Reduces the Toxic Effects and Allows Increasing of Dose in Dose-dependent Protocol in Mice Infected with Trypanosoma cruzi

Although several diseases are treated by toxic drugs, their side effects may hamper adherence to the therapy. The aim of this study is evaluate effect association ponderal benznidazole (BZ) with its ultra-high diluted (UHD) formula on clinical and parasitological parameters mice infected Trypanosoma cruzi (T. cruzi). 24 non-isogenic Swiss were divided into groups: CI – animals 7% alcohol; BZp BZ (500 mg/ kg) from beginning infection; BZp+d UHD BZ, which started be administered four days after treatment BZ; CNI - group non-treated non-infected animals. medicine was prepared according Phamacopoeia until 30x. different schedules statistically compared through parameters. displayed more favorable evolution than BZp, improvement mass gain, feed conversion water intake, presenting data approximated group. significant increase body temperature indicates an activation immune system not observed in other groups. Moreover, anti-parasitic drug maintained all By reducing maintaining action drug, combination drugs could considered a way improving efficacy treatment.